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The Clemson Tigers are on the road in Louisville Friday night as they are set to face off against the host Cardinals. The Tigers had won eight straight meetings between these two teams before coming up short last season at home as a double-digit favorite losing to the Cardinals 33 to 21. Will the Tigers want to avenge that home loss of course they will but you must have the players and scheme to get the job done. Clemson is coming off a big win over a hated rival last week as they defeated FSU 24 to 10. While Louisville was busy coming off a shocking overtime loss to the Golden Bears of Cal as nineteen-point home chalk. Could they have gotten caught looking ahead to this huge game against the Tigers? Yes that would help explain the loss for sure, but you never know for sure, but it makes a lot of sense. The Cards rushing attack led by Keyjuan Brown who rushed for 136 yards on fourteen carries (148 total rushing yds) and they needed that because Moss had just 203 yards passing in the loss. Earlier in the campaign the Cardinals used their air attack because they had almost every one of their running back on injured reserve and were not able to play. Since the return of Isaac Brown and Keyjuan Brown Louisville has rushed for 317, 235 and 148 yards over the last three weeks. The Tigers rush defense can be exploited by a good rushing attack and that is exactly what the Cardinals have. With the Cards establishing their run game that will keep the Tigers offense on the bench. We also know the Tigers defense has their pass defense as their biggest weakness. The Cards should be able to find some consistent passing opportunities that are made available by their successful running game. The Tigers rank outside the top 100 in passing yards allowed per game. On the defensive side for the Cardinals, we know they have a solid defensive unit. They have faced tougher offenses than they will face tonight including the Hurricanes, Panthers and Cavaliers which all have a more dangerous offense than the Tigers. Our TPR Index projects a point advantage of 7.79 points. The MM projects a point differential of +5.32 points against the current line range in this contest. The SIM Matrix has the Cardinals with a 73.99 percent advantage against the oddsmakers number in tonight’s game. The OFF-DEF splits have the Cardinals with a 5.16-point advantage against the current number in tonight’s game. This game sets up as a double in our Reverse Momentum Matrix with the Tigers coming off a huge rivalry win while the Cardinals are coming off a double-digit home upset loss. The Tigers are trending solidly in negative territory while the Cardinals are trending in positive territory across the board. The Tigers have a game average in the Reverse Matrix of just 5.01 while the Cardinals have a game average of 8.64. The difference in this matrix of +3.63 translates into a 5.25-point plus win by the Cardinals. Play ON CFB conference home favorites of 7 or fewer points coming off a SU loss as a double-digit home favorite with a MM advantage of +5.25 or better, SIM advantage of 73.80 percent, and a RMM differential of +3.50 or better, 118-59-4 ATS (67%)(+$7,118) including 14-3-1 ATS (82%)! Lay the short price with the Cardinals as they get a huge win in Louisville on Friday night. PREDICTION: 8* LOUISVILLE CARDINALS 28 CLEMSON TIGERS 20