Free Sports Game Preview and Prediction: Tennessee Titans vs. San Francisco 49ers
Sunday, December 14, 2025 4:25 PM
Play: Point Spread: -13/-105 San Francisco 49ers
San Francisco comes off a bye, a spot where they’ve thrived, winning their last three post-bye openers by a combined 79-39. They enter on a three-game win streak and sit 8-5 ATS, consistently rewarding backers. Expect a heavy dose of Christian McCaffrey, who’s averaged 19 carries, 5.3 catches and 337 total yards over his last three games. When Brock Purdy avoids turnovers, this offense is extremely difficult to slow down.
Tennessee, meanwhile, is fresh off just its second win of the season, making this a prime letdown spot. Even in victory, Cam Ward threw for only 117 yards at 50% completion, and the offense relied almost entirely on Tony Pollard’s 161 rushing yards. That won’t come easy against a 49ers defense that has allowed only four opponents all year to top 100 rushing yards.
If the Titans can’t run, the game falls on Ward’s shoulders, and that’s a matchup San Francisco will gladly take.
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