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Home / Articles / Free Sports Game Preview and Prediction: Arizona Cardinals vs. San Francisco 49ers (NFL)

Free Sports Game Preview and Prediction: Arizona Cardinals vs. San Francisco 49ers (NFL)

By: Joe D'Amico     Date: Sep 24, 2026
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Free Sports Game Preview and Prediction: Arizona Cardinals vs. San Francisco 49ers
Sunday, September 27, 2026 4:05 PM
Play: Point Spread: -9/-105 San Francisco 49ers
Join me this Sunday in the NFL as we continue to BEAT THE BOOKS on the pro gridiron. I am riding a 60% NFL RUN, and this Sunday, we take it up a notch with 3 BIG WINNERS: HUGE 1-0 CONSENSUS, AFC NORTH GAME OF THE MONTH BENGALS/STEELERS WINNER, and my BIG BIG BIG GAME WINNER 1-0 HI ROLLER. Sunday Free Winner: San Francisco 49ers. Game 482. 1:05 PM PST/4:05 PM EST. San Francisco has dominated their division rival, taking six of the last eight meetings SU, going 5-3 ATS during that span. They are looking strong so far this season sporting a 2-0 record both SU/ATS as their offense ranks in the top-10 in just about every major category, including the one that means the most, scoring where they average over 31.0 PPG. By the way, very uncharacteristic for teams at the start of a season, they’ve also only turned the ball over once. Meanwhile, the Arizona Cardinals look to be a trainwreck. Yes, they did open up their season on the road with a big surprise victory over the Los Angeles Chargers as nearly a double-digit underdog. But last week came back down to Earth as they got shellacked at home by the Seattle Seahawks, 31-7. This team has a lot of problems, my friends. Scoring is certainly one of them. If you like numbers, you’ll love these: Arizona is 1-10 SU in their last 11 divisional games and 1-9 ATS as divisional underdogs of seven or more points. They were also winless against the NFC West last season (0-6). With Jacoby Brissett at the helm, I doubt very much they’re going to be able to move the chains at all here. The 49ers defense looks solid and remember, they have the luxury of something they haven’t had in the past, some of their biggest names are healthy. San Francisco is a well-coached, smart team. Although they have Denver up next followed by a road game at Seattle, I doubt very much they’re going to be in a look ahead mode here. They know these division victories mean a lot. This is their final chance to find tune their team on both side sides of the line of scrimmage before their schedule gets more difficult. Take the San Francisco 49ers. Thank you.
 

  Joe D'Amico

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