Los Angeles Dodgers at Colorado Rockies, 3:05pm ET Derek Lowe (2-1, 2.88 ERA) vs. Aaron Cook (4-1, 2.41 ERA)

Lowe gave up six runs in a no-decision versus the Marlins last time out, but only three of those runs were earned. That kept the righthander's ERA under 3.00 for the season. Lowe has allowed three or fewer earned runs in each of his six starts so far in 2008, but he's only managed to pick up two wins for his troubles, with one defeat and three NDs.

Cook has been on fire for the Rockies, as he's earned the victory in each of his last four outings. The righthander surrendered just six earned runs over 28 innings in those starts to drop his ERA below 2.50 in 2008. Cook held the Giants to just two unearned runs on Tuesday, giving up 10 hits and two walks and fanning three over seven innings.

New York Mets at Arizona Diamondbacks, 4:10pm ET Johan Santana (3-2, 3.12 ERA) vs. Dan Haren (4-1, 3.13 ERA)

Santana could only manage a no-decision in his start versus the Pirates on Tuesday, but he allowed just two earned runs on two hits over 5 2-3 innings of work and struck out seven batters. The lefthander has allowed more than three earned runs in only one start so far this season (on April 12 versus the Brewers), and he's struck out 39 batters.

Haren has also allowed more than three earned runs in only one start this year - that came on April 23 when the Dodgers got to him for five earned runs over 4 2-3 innings. The righthander has picked up either a win or a no-decision in each of his other five outings, and he only walked seven batters (while striking out 29) in his six starts in April.

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