San Francisco 49ers vs. Indianapolis Colts (NFL) - Aug 15, 2010 1:00 PM EDT Play on : San Francisco 49ers

Very seldom do you see a road team favored by this many points during the preseason. The reason is the quarterback rotation and the 49ers have a major edge once the Colts replace Peyton Manning in the first quarter of this afternoon game. After Manning expect to see a combination of Curtis Painter, Tom Brandstater, and Tom Hiller. Longtime back-up QB Jim Sorgi has moved onto the Giants to play under Eli Manning and that leaves a major void for the Colts once Manning is out of the game. Curtis Painter had limited action late during the regular season last year and played terrible.

The 49ers have Alex Smith and David Carr as their first two quarterbacks and both of them have started many games in the league. That will allow them to be up at halftime and coast to a victory in the second half. Mike Singletary is 3-1 in preseason action during his tenure. Jim Caldwell is 1-3 in his four preseason games. Doc’s Sports has you covered with a full slate of Week 1 winners and now is the time to jump on board a veteran handicapper with 39 years of experience for the upcoming NFL and College Football Season.
 

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